Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 3/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 6/20 | 0.39 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.38 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 2/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30658056 | 1.00 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL30658017 | 0.90 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL26654083 | 0.90 | SMARCA2 (0.55) | SMARCA2SMARCA4PBRM1CCNKCDK12 | |
| SCHEMBL26654056 | 0.86 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL30658000 | 0.86 | SMARCA2 (0.38) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL24461312 | 0.84 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL29619413 | 0.84 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1BACE1BACE2 | |
| SCHEMBL30658057 | 0.80 | KDM4E (0.40) | BACE1BACE2CCNKCDK12KDM4E | |
| SCHEMBL26653835 | 0.80 | KDM4E (0.40) | BACE1BACE2CCNKCDK12KDM4E | |
| SCHEMBL26654087 | 0.79 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1KDM4EIDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC (US) | 2025-10-02 | — | — | US | disclosed |
| CN-120035593-A | Pyrazine derivatives and uses thereof | 福宏治疗公司 | 2025-05-23 | — | — | CN | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250302832-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | BRCA1, VHL, SF3B5 | SMARCA2 77/4885SMARCA4 19/4885PBRM1 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.