Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 5/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 3/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 3/20 | 0.44 |
| ▸ | PBRM1 | Q86U86 | 3/20 | 0.44 |
| ▸ | CHUK | O15111 | 2/20 | 0.42 |
| ▸ | APP | P05067 | 4/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22777062 | 1.00 | IKBKB (0.48) | IKBKBHTR2CADRB2SMARCA2SMARCA4 | |
| SCHEMBL24461294 | 0.93 | IKBKB (0.44) | IKBKBHTR2CADRB2SMARCA2SMARCA4 | |
| SCHEMBL30552534 | 0.88 | PBRM1 (0.40) | IKBKBSMARCA2SMARCA4PBRM1CHUK | |
| SCHEMBL24461290 | 0.88 | PBRM1 (0.40) | IKBKBSMARCA2SMARCA4PBRM1CHUK | |
| SCHEMBL22777840 | 0.87 | PBRM1 (0.39) | IKBKBHTR2CADRB2SMARCA2SMARCA4 | |
| SCHEMBL22790943 | 0.86 | CYP1A2 (0.49) | SMARCA2SMARCA4PBRM1APP | |
| SCHEMBL22791037 | 0.86 | PBRM1 (0.40) | IKBKBHTR2CADRB2SMARCA2SMARCA4 | |
| SCHEMBL24461315 | 0.83 | KDM4E (0.39) | IKBKBSMARCA2SMARCA4PBRM1CHEK2 | |
| SCHEMBL25467865 | 0.83 | PBRM1 (0.40) | IKBKBSMARCA2SMARCA4PBRM1CHUK | |
| SCHEMBL27052473 | 0.83 | PBRM1 (0.39) | IKBKBSMARCA2SMARCA4PBRM1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022109426-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2022-05-27 | — | — | WO | disclosed |