Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 10/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 9/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 9/20 | 0.40 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24461290 | 1.00 | PBRM1 (0.40) | PBRM1SMARCA2SMARCA4IKBKBCHUK | |
| SCHEMBL24461294 | 0.91 | IKBKB (0.44) | PBRM1SMARCA2SMARCA4IKBKBCHUK | |
| SCHEMBL29619417 | 0.88 | IKBKB (0.48) | PBRM1SMARCA2SMARCA4IKBKBCHUK | |
| SCHEMBL22777062 | 0.88 | IKBKB (0.48) | PBRM1SMARCA2SMARCA4IKBKBCHUK | |
| SCHEMBL24461315 | 0.85 | KDM4E (0.39) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 | |
| SCHEMBL27052473 | 0.85 | PBRM1 (0.39) | PBRM1SMARCA2SMARCA4IKBKBCHUK | |
| SCHEMBL22790943 | 0.83 | CYP1A2 (0.49) | PBRM1SMARCA2SMARCA4 | |
| SCHEMBL24461486 | 0.82 | HSD11B1 (0.38) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL24461436 | 0.82 | PBRM1 (0.38) | PBRM1SMARCA2SMARCA4NR1I2BRD4 | |
| SCHEMBL24461129 | 0.82 | SMARCA2 (0.45) | PBRM1SMARCA2SMARCA4IKBKBNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116744929-A | Compounds and uses thereof | 福霍恩治疗公司 | 2023-09-12 | — | — | CN | disclosed |