Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 2/20 | 0.70 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.69 |
| ▸ | DDB1 | Q16531 | 7/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.58 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.57 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.56 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21070244 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| SCHEMBL29622326 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| SCHEMBL29622211 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| SCHEMBL17859010 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| SCHEMBL17859058 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| SCHEMBL24142023 | 1.00 | STAT3 (0.70) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| Hydrochloric Acid SCHEMBL22263309 | 0.99 | STAT3 (0.69) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| Hydrochloric Acid SCHEMBL22263317 | 0.99 | STAT3 (0.69) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| Hydrochloric Acid SCHEMBL22263290 | 0.99 | STAT3 (0.69) | STAT3CRBNHDAC1HDAC6HDAC3 | |
| Hydrochloric Acid SCHEMBL31083322 | 0.99 | STAT3 (0.69) | STAT3CRBNHDAC1HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240150328-A1 | METHODS AND COMPOUNDS FOR TREATING DISORDERS | FOGHORN THERAPEUTICS INC. | 2024-05-09 | — | — | US | disclosed |
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-11-02 | — | — | US | disclosed |
| US-11773085-B2 | Methods and compounds for treating disorders | FOGHORN THERAPEUTICS INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-20230150974-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. | 2023-05-18 | — | — | US | disclosed |
| WO-2022086937-A9 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-02-02 | — | — | WO | disclosed |
| WO-2022086937-A1 | HETEROBIFUNCTIONAL COMPOUNDS AS DEGRADERS OF ENL | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230150974-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, TFEB | STAT3 3892/4885CRBN 179/4885HDAC1 242/4885 |
| US-20230348452-A1 | COMPOUNDS AND USES THEREOF | VHL, CLN6, BRCA1 | STAT3 3997/4885CRBN 163/4885HDAC1 378/4885 |
| US-11773085-B2 | Methods and compounds for treating disorders | VHL, TFEB, BECN1 | STAT3 3153/4885CRBN 287/4885HDAC1 373/4885 |
| US-20240150328-A1 | METHODS AND COMPOUNDS FOR TREATING DISORDERS | VHL, TFEB, BECN1 | STAT3 3153/4885CRBN 287/4885HDAC1 373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.