Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.56 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | F10 | P00742 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22972144 | 1.00 | AKR1C3 (0.56) | AKR1C3LOXL2MRGPRX4KDRBRAF | |
| SCHEMBL29622884 | 0.88 | TNKS (0.51) | KDRBRAFMAPK14TNNI3KF2 | |
| SCHEMBL24724269 | 0.88 | MEN1 (0.58) | KDRBRAFMAPK14TNNI3KGPBAR1 | |
| SCHEMBL24724243 | 0.88 | TNKS (0.51) | KDRBRAFMAPK14TNNI3KF2 | |
| SCHEMBL29622922 | 0.88 | TNKS (0.51) | KDRBRAFMAPK14TNNI3KF2 | |
| SCHEMBL24724242 | 0.85 | KDR (0.50) | KDRBRAFMAPK14TNNI3KAR | |
| SCHEMBL7237590 | 0.83 | TTR (0.54) | AKR1C3KDRTTR | |
| SCHEMBL22972360 | 0.83 | LOX (0.62) | LOXL2AR | |
| SCHEMBL22972145 | 0.83 | DDR2 (0.54) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL30050285 | 0.83 | DDR2 (0.54) | KDRBRAFMAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114391009-A | Quinoline derivatives as protein kinase inhibitors | BCI制药公司 | 2022-04-22 | — | — | CN | disclosed |