Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197061 | 0.82 | KDM4E (0.40) | ALDH1A1MAPTTDP1L3MBTL1GABRA1 | |
| SCHEMBL13199750 | 0.82 | MAPT (0.49) | ALDH1A1MAPTLMNAL3MBTL1PRNP | |
| SCHEMBL2956556 | 0.78 | MIF (0.45) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL2962468 | 0.78 | MIF (0.51) | ALDH1A1MAPTTDP1LMNAL3MBTL1 | |
| SCHEMBL2955526 | 0.77 | GABRA1 (0.48) | ALDH1A1MAPTLMNAGABRA1MIF | |
| SCHEMBL13199741 | 0.77 | MIF (0.43) | ALDH1A1MAPTLMNAL3MBTL1TSHR | |
| SCHEMBL2958056 | 0.75 | HDAC1 (0.40) | MAPTL3MBTL1GABRA1MIFKDM4E | |
| SCHEMBL2964410 | 0.74 | GABRA1 (0.43) | ALDH1A1MAPTTDP1LMNAGABRA1 | |
| SCHEMBL13199735 | 0.74 | MIF (0.45) | ALDH1A1MAPTTDP1LMNAL3MBTL1 | |
| SCHEMBL2959066 | 0.74 | GABRA1 (0.50) | ALDH1A1MAPTLMNAL3MBTL1GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7767665-B2 | 3-[6-(4-oxo-4H-1,3-benzothiazin-2-yl)-2-pyridyl]propionic acid, having an excellent apoptosis inhibitory and Macrophage migration inhibitory factor (MIF) binding effects, used for preventing and/or treating cancers, AIDS, cardiovascular, neurodegeneartive, bone, kidney and liver disoders | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-08-03 | — | — | US | disclosed |
| US-7399759-B2 | 1, 3-benzothiazinone derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-07-15 | — | — | US | disclosed |