Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 12/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.61 |
| ▸ | KDR | P35968 | 5/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 10/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.55 |
| ▸ | KIT | P10721 | 4/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.55 |
| ▸ | LCK | P06239 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | CDK8 | P49336 | 2/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.55 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.55 |
| ▸ | MUSK | O15146 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623675 | 1.00 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL19350961 | 1.00 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL19350840 | 1.00 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL29623245 | 0.93 | RET (0.64) | FLT3NTRK1KDRAURKARET | |
| SCHEMBL19350793 | 0.93 | RET (0.64) | FLT3NTRK1KDRAURKARET | |
| SCHEMBL29623585 | 0.90 | FLT3 (0.64) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL19350843 | 0.90 | FLT3 (0.64) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL20627772 | 0.88 | FLT3 (0.55) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL20627506 | 0.88 | FLT3 (0.55) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL29623342 | 0.88 | RET (0.53) | FLT3NTRK1KDRRETCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | claimed |
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |