Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 8/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.55 |
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 5/20 | 0.44 |
| ▸ | CSF1R | P07333 | 3/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.42 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.42 |
| ▸ | PAK3 | O75914 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20627772 | 1.00 | FLT3 (0.55) | FLT3NTRK1KDRFGFR1SRC | |
| SCHEMBL29623418 | 0.88 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL19350840 | 0.88 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL19350961 | 0.88 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL29623675 | 0.88 | FLT3 (0.63) | FLT3NTRK1KDRALKAURKA | |
| SCHEMBL20627743 | 0.85 | FGFR1 (0.52) | FLT3NTRK1KDRFGFR1SRC | |
| SCHEMBL19350793 | 0.81 | RET (0.64) | FLT3NTRK1KDRFGFR1SRC | |
| SCHEMBL29623245 | 0.81 | RET (0.64) | FLT3NTRK1KDRFGFR1SRC | |
| SCHEMBL20627759 | 0.80 | NTRK1 (0.66) | FLT3NTRK1KDRFGFR1SRC | |
| SCHEMBL29623585 | 0.78 | FLT3 (0.64) | FLT3NTRK1KDRALKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-A1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Ancureall Pharmaceutical (Shanghai) Co., Ltd. (CN) | 2019-01-09 | — | — | EP | disclosed |