Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.80 |
| ▸ | SRC | P12931 | 5/20 | 0.80 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.48 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19350877 | 1.00 | FGFR1 (0.80) | FGFR1SRCKDRALDH1A1MAPT | |
| SCHEMBL19350931 | 0.95 | FGFR1 (0.80) | FGFR1SRCKDRALDH1A1MAPT | |
| SCHEMBL19350894 | 0.91 | FGFR1 (0.67) | FGFR1SRCKDRALDH1A1CYP1A2 | |
| SCHEMBL7990149 | 0.89 | FGFR1 (1.00) | FGFR1SRCKDRRAB9AMCHR1 | |
| SCHEMBL20604018 | 0.89 | FGFR1 (0.63) | FGFR1SRCKDRALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL7987479 | 0.88 | FGFR1 (0.98) | FGFR1SRCKDRRAB9ANPC1 | |
| SCHEMBL20603905 | 0.87 | FGFR1 (0.73) | FGFR1SRCKDRALDH1A1SMN1; SMN2 | |
| SCHEMBL20627495 | 0.84 | FGFR1 (0.71) | FGFR1SRCKDRALDH1A1CYP1A2 | |
| SCHEMBL7986193 | 0.83 | FGFR1 (1.00) | FGFR1SRCKDR | |
| SCHEMBL20604001 | 0.83 | FGFR1 (0.73) | FGFR1SRCKDRSMN1; SMN2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | claimed |
| EP-3424924-B1 | UREA COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | ANCUREALL PHARMACEUTICAL SHANGHAI CO LTD (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |