Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 2/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.40 |
| ▸ | MERTK | Q12866 | 4/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL31614377 | 0.99 | KMT2A (0.47) | KMT2AMAPK1METTYRO3MERTK | |
| SCHEMBL14969331 | 0.88 | KMT2A (0.44) | KMT2AMETTYRO3MERTKKDM4E | |
| SCHEMBL30030688 | 0.87 | KMT2A (0.39) | KMT2AMAPK1METTYRO3MERTK | |
| SCHEMBL19398124 | 0.87 | KDM4E (0.45) | KMT2AMETTYRO3MERTKKDM4E | |
| SCHEMBL30030585 | 0.86 | AXL (0.41) | KMT2AMAPK1METTYRO3MERTK | |
| SCHEMBL29536487 | 0.86 | AXL (0.47) | METTYRO3MERTKAXL | |
| Hydrochloric Acid SCHEMBL30297740 | 0.85 | AXL (0.47) | METTYRO3MERTKAXL | |
| SCHEMBL29626219 | 0.84 | PDE4A (0.42) | KMT2AMAPK1METMERTKGSK3A | |
| SCHEMBL29626208 | 0.84 | AXL (0.48) | KMT2AMETTYRO3MERTKAXL | |
| SCHEMBL30672108 | 0.84 | TYRO3 (0.43) | KMT2AMETTYRO3AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | claimed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | claimed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | claimed |
| CN-114456175-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-09-03 | — | — | CN | disclosed |
| CN-114456176-B | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2024-08-30 | — | — | CN | disclosed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |