Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPD | P32754 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.37 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19377769 | 0.89 | ALKBH5 (0.43) | PDE4AGSK3AGSK3BKMT2AHPD | |
| SCHEMBL29626208 | 0.85 | AXL (0.48) | KMT2AHPDAXLMERTKPARP1 | |
| SCHEMBL29625543 | 0.84 | KMT2A (0.48) | GSK3AGSK3BKMT2AAXLMERTK | |
| Hydrochloric Acid SCHEMBL31614377 | 0.83 | KMT2A (0.47) | GSK3AGSK3BKMT2AAXLMERTK | |
| SCHEMBL30672101 | 0.82 | ADRA1D (0.46) | PDE4AKMT2AMERTKKCNH2 | |
| SCHEMBL30030688 | 0.78 | KMT2A (0.39) | KMT2AHPDAXLMERTKMEN1 | |
| SCHEMBL30672108 | 0.78 | TYRO3 (0.43) | KMT2AAXLALDH1A1MET | |
| SCHEMBL30030585 | 0.77 | AXL (0.41) | GSK3AGSK3BKMT2AAXLMERTK | |
| SCHEMBL29536487 | 0.77 | AXL (0.47) | AXLMERTKMET | |
| Hydrochloric Acid SCHEMBL30297740 | 0.76 | AXL (0.47) | AXLMERTKMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| CN-114456175-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |
| CN-114456176-A | Pyrrolotriazine compounds as TAM inhibitors | 因赛特公司 | 2022-05-10 | — | — | CN | disclosed |