Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 19/20 | 1.00 |
| ▸ | TLR8 | Q9NR97 | 19/20 | 1.00 |
| ▸ | TLR7 | Q9NYK1 | 19/20 | 1.00 |
| ▸ | GNRHR | P30968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554574 | 1.00 | TLR9 (1.00) | TLR9TLR8TLR7GNRHR | |
| SCHEMBL22554690 | 0.82 | TLR9 (0.70) | TLR9TLR8TLR7 | |
| SCHEMBL30467011 | 0.82 | TLR9 (0.70) | TLR9TLR8TLR7 | |
| SCHEMBL22554498 | 0.81 | TLR7 (1.00) | TLR9TLR8TLR7 | |
| SCHEMBL30466885 | 0.81 | TLR7 (1.00) | TLR9TLR8TLR7 | |
| SCHEMBL22554600 | 0.80 | TLR8 (1.00) | TLR9TLR8TLR7GNRHR | |
| SCHEMBL30466886 | 0.80 | TLR8 (1.00) | TLR9TLR8TLR7GNRHR | |
| SCHEMBL22554681 | 0.80 | TLR8 (0.66) | TLR9TLR8TLR7 | |
| SCHEMBL30466997 | 0.80 | TLR8 (0.66) | TLR9TLR8TLR7 | |
| SCHEMBL22554604 | 0.80 | TLR9 (1.00) | TLR9TLR8TLR7GNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | claimed |
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | disclosed |
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |