Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 19/20 | 1.00 |
| ▸ | TLR7 | Q9NYK1 | 19/20 | 1.00 |
| ▸ | TLR9 | Q9NR96 | 17/20 | 1.00 |
| ▸ | GNRHR | P30968 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466886 | 1.00 | TLR8 (1.00) | TLR8TLR7TLR9GNRHR | |
| SCHEMBL22554564 | 0.85 | TLR8 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL22554632 | 0.82 | TLR8 (0.68) | TLR8TLR7TLR9 | |
| SCHEMBL30467020 | 0.82 | TLR8 (0.68) | TLR8TLR7TLR9 | |
| SCHEMBL29626555 | 0.80 | TLR9 (1.00) | TLR8TLR7TLR9GNRHR | |
| SCHEMBL22554574 | 0.80 | TLR9 (1.00) | TLR8TLR7TLR9GNRHR | |
| SCHEMBL22554700 | 0.79 | TLR8 (0.65) | TLR8TLR7TLR9 | |
| SCHEMBL30467010 | 0.79 | TLR8 (0.65) | TLR8TLR7TLR9 | |
| SCHEMBL22554498 | 0.74 | TLR7 (1.00) | TLR8TLR7TLR9 | |
| SCHEMBL30466885 | 0.74 | TLR7 (1.00) | TLR8TLR7TLR9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | claimed |
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-23 | — | — | US | claimed |
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | claimed |
| EP-3728221-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | Bristol-Myers Squibb Company (US) | 2020-10-28 | — | — | EP | claimed |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | PROTIX B.V. (NL) | 2020-10-22 | — | — | US | claimed |
| CN-111511730-B | Amide substituted indole compounds useful as TLR inhibitors | 百时美施贵宝公司 | 2023-07-25 | — | — | CN | disclosed |
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-23 | — | — | US | disclosed |
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-08-23 | — | — | US | disclosed |
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3728221-B1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2022-06-01 | — | — | EP | disclosed |
| EP-3728221-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | Bristol-Myers Squibb Company (US) | 2020-10-28 | — | — | EP | disclosed |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | PROTIX B.V. (NL) | 2020-10-22 | — | — | US | disclosed |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | PROTIX B.V. (NL) | 2020-10-22 | — | — | US | disclosed |
| CN-111511730-A | Amide substituted indole compounds useful as T L R inhibitors | 百时美施贵宝公司 | 2020-08-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11420973-B2 | Amide substituted indole compounds useful as TLR inhibitors | TLR9, TLR1, TLR7 | TLR8 4/4885TLR7 3/4885TLR9 1/4885 |
| US-20200331920-A1 | AMIDE SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR INHIBITORS | TLR9, TLR1, TLR7 | TLR8 4/4885TLR7 3/4885TLR9 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.