Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.58 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL435325 | 1.00 | TSHR (0.61) | TSHRTP53PDCD1CD274LMNA | |
| Ammonia Solution, Strong SCHEMBL16468685 | 0.98 | TSHR (0.59) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL319947 | 0.89 | CA1 (0.59) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL13516938 | 0.85 | TSHR (0.59) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL7917038 | 0.85 | RAB9A (0.50) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL902823 | 0.85 | CA1 (0.52) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL6660758 | 0.84 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL10239104 | 0.84 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL29311500 | 0.84 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA | |
| SCHEMBL13700339 | 0.84 | TSHR (0.63) | TSHRTP53PDCD1CD274LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4003965-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | Nurix Therapeutics, Inc. (US) | 2022-06-01 | — | — | EP | disclosed |