Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.54 |
| ▸ | THPO | P40225 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22953425 | 1.00 | CYP3A4 (0.54) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL22953713 | 0.89 | CYP3A4 (0.54) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL29869900 | 0.89 | CYP3A4 (0.54) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL11102977 | 0.80 | PARP1 (0.68) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL14494799 | 0.80 | PARP1 (0.68) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL22953455 | 0.78 | PDE4A (0.41) | CYP3A4TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL29626856 | 0.78 | PDE4A (0.41) | CYP3A4TSHRKDM4EHPGDALDH1A1 | |
| Bromide SCHEMBL8905972 | 0.78 | KDM4E (0.59) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| SCHEMBL22953723 | 0.76 | MAPK1 (0.52) | CYP3A4MAPK1NFKB1THPOHSD17B10 | |
| Bromide SCHEMBL8904455 | 0.76 | KDM4E (0.56) | CYP3A4MAPK1NFKB1THPOHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220267277-A1 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2022-08-25 | — | — | US | disclosed |
| EP-4003339-A2 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2022-06-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220267277-A1 | DOPAMINE RECEPTOR D1 AGONISTS AND METHODS OF USE | PRLHR, YAP1, MST1R | CYP3A4 4707/4885MAPK1 1277/4885NFKB1 4284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.