Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 13/20 | 0.63 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.63 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5987034 | 1.00 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2955099 | 1.00 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7684237 | 0.85 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL7687962 | 0.85 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5986516 | 0.82 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5997195 | 0.82 | CHRNB4 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5988311 | 0.81 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2955827 | 0.81 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2961161 | 0.81 | CHRNB2 (0.55) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2962720 | 0.80 | CHRNB2 (0.41) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE41439-E1 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. (US) | 2010-07-13 | — | — | US | disclosed |