Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.54 |
| ▸ | RAF1 | P04049 | 4/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 4/20 | 0.51 |
| ▸ | CCNC | P24863 | 3/20 | 0.51 |
| ▸ | KDR | P35968 | 5/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | ARAF | P10398 | 2/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23068665 | 1.00 | BRAF (0.54) | BRAFRAF1MAPK14CDK8CCNC | |
| SCHEMBL22684884 | 0.93 | CDK2 (0.47) | BRAFRAF1MAPK14CDK8CCNC | |
| SCHEMBL22684877 | 0.92 | CDK2 (0.49) | BRAFRAF1MAPK14CDK8CCNC | |
| SCHEMBL23068631 | 0.91 | CDK2 (0.48) | BRAFRAF1MAPK14CDK8KDR | |
| SCHEMBL29629220 | 0.91 | CDK2 (0.48) | BRAFRAF1MAPK14CDK8KDR | |
| SCHEMBL29629193 | 0.90 | BLM (0.49) | BRAFRAF1MAPK14KDRBLM | |
| SCHEMBL23068623 | 0.90 | BLM (0.49) | BRAFRAF1MAPK14KDRBLM | |
| SCHEMBL23068691 | 0.88 | CDK2 (0.48) | BRAFRAF1MAPK14KDRBLM | |
| SCHEMBL22684844 | 0.88 | CDK2 (0.51) | KDRBLMCCNA2CDK2CDK4 | |
| SCHEMBL29629247 | 0.88 | CDK2 (0.51) | KDRBLMCCNA2CDK2CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2023-03-23 | — | — | US | disclosed |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | AUCENTRA HOLDINGS PTY LTD (AU) | 2022-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | CDK8, CDK18, CDK9 | BRAF 556/4885RAF1 460/4885MAPK14 446/4885 |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | CDK8, CDK18, CDK9 | BRAF 556/4885RAF1 460/4885MAPK14 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.