Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.58 |
| ▸ | TEK | Q02763 | 3/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.58 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 8/20 | 0.52 |
| ▸ | CDK4 | P11802 | 3/20 | 0.52 |
| ▸ | YES1 | P07947 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.49 |
| ▸ | CDK9 | P50750 | 5/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CDK7 | P50613 | 3/20 | 0.49 |
| ▸ | CCNH | P51946 | 3/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22684846 | 1.00 | KDR (0.58) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL23068620 | 0.89 | CDK2 (0.57) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL22684862 | 0.88 | KDR (0.49) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL29629250 | 0.88 | KDR (0.49) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL29629230 | 0.88 | CDK2 (0.57) | KDRTEKCDK2CDK4CCNA2 | |
| SCHEMBL23068638 | 0.88 | CDK2 (0.57) | KDRTEKCDK2CDK4CCNA2 | |
| SCHEMBL23068632 | 0.87 | MAPT (0.47) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL29629212 | 0.87 | MAPT (0.47) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL23068675 | 0.86 | CDK2 (0.50) | KDRTEKMAPK14BRAFTNNI3K | |
| SCHEMBL23068661 | 0.86 | CDK2 (0.50) | KDRTEKMAPK14BRAFTNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111757881-B | 5- (Pyrimidin-4-yl) thiazol-2-yl urea derivatives as therapeutic agents | 澳升医药公司 | 2024-05-07 | — | — | CN | claimed |
| CN-111757881-B | 5- (Pyrimidin-4-yl) thiazol-2-yl urea derivatives as therapeutic agents | 澳升医药公司 | 2024-05-07 | — | — | CN | disclosed |
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | AUCENTRA THERAPEUTICS PTY LTD (AU) | 2023-03-23 | — | — | US | disclosed |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | AUCENTRA HOLDINGS PTY LTD (AU) | 2022-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230092876-A1 | 5-(PYRIMIDIN-4-YL)THIAZOL-2-YL UREA DERIVATIVES AS THERAPEUTIC AGENTS | CDK8, CDK18, CDK9 | KDR 3235/4885TEK 2224/4885MAPK14 446/4885 |
| US-11325900-B2 | 5-(pyrimidin-4-yl)thiazol-2-yl urea derivatives as therapeutic agents | CDK8, CDK18, CDK9 | KDR 3235/4885TEK 2224/4885MAPK14 446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.