Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NAAA | Q02083 | 2/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21572796 | 1.00 | ALDH1A1 (0.47) | ALDH1A1MAPK1L3MBTL1GAAENPP2 | |
| SCHEMBL21249535 | 0.87 | GAA (0.47) | ALDH1A1L3MBTL1GAALMNAABCC4 | |
| SCHEMBL21572799 | 0.87 | GAA (0.47) | ALDH1A1L3MBTL1GAALMNAABCC4 | |
| SCHEMBL20583484 | 0.86 | ALDH1A1 (0.50) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL20583485 | 0.86 | ALDH1A1 (0.50) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL20583575 | 0.84 | TSHR (0.50) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL20583574 | 0.84 | TSHR (0.50) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL21572785 | 0.82 | GAA (0.45) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL18970284 | 0.82 | ABCC4 (0.55) | ALDH1A1GAALMNAABCC4TSHR | |
| SCHEMBL18970304 | 0.82 | ABCC4 (0.55) | ALDH1A1GAALMNAABCC4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424899-B1 | SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-05-11 | — | — | EP | disclosed |