SCHEMBL29630263

SCHEMBL29630263

OCc1cccnc1OC(F)F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
TRPV4 Q9HBA0 1/20 0.49
L3MBTL1 Q9Y468 2/20 0.39
KDM4E B2RXH2 2/20 0.39
NPC1 O15118 2/20 0.39
LMNA P02545 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
GAA P10253 1/20 0.39
HTT P42858 1/20 0.39
SLC13A5 Q86YT5 1/20 0.37
LIPG Q9Y5X9 2/20 0.37
ALDH1A1 P00352 1/20 0.36
MAPK1 P28482 1/20 0.35
RUNX1 Q01196 1/20 0.35
NR3C1 P04150 1/20 0.34
PGR P06401 1/20 0.34
GRIN1 Q05586 2/20 0.33
GRIN2B Q13224 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23286941 1.00 MEN1 (0.51) MEN1KMT2ATRPV4L3MBTL1KDM4E
SCHEMBL21246452 0.82 TRPV4 (0.53) MEN1KMT2ATRPV4NPC1LMNA
SCHEMBL28298278 0.82 TRPV4 (0.49) MEN1KMT2ATRPV4NPC1LMNA
SCHEMBL24689614 0.82 TRPV4 (0.53) MEN1KMT2ATRPV4L3MBTL1LMNA
SCHEMBL23286944 0.82 TRPV4 (0.49) MEN1KMT2ATRPV4NPC1LMNA
SCHEMBL2894151 0.82 MEN1 (0.55) MEN1KMT2AL3MBTL1KDM4ENPC1
SCHEMBL28824721 0.79 TRPV4 (0.46) MEN1KMT2ATRPV4NPC1RAB9A
SCHEMBL2376205 0.76 TRPV4 (0.54) MEN1KMT2ATRPV4KDM4ESMN1; SMN2
SCHEMBL2376210 0.76 TRPV4 (0.54) MEN1KMT2ATRPV4LMNASLC13A5
SCHEMBL31365171 0.76 MEN1 (0.60) MEN1KMT2AL3MBTL1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119874674-A GLP-1R modulating compounds 吉利德科学公司 2025-04-25 CN disclosed
CN-114630823-B GLP-1R Modulating Compounds 吉利德科学公司 2025-01-28 CN disclosed
EP-4048664-A1 GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES, INC. (US) 2022-08-31 EP disclosed
CN-114630823-A GLP-1R modulating compounds 吉利德科学公司 2022-06-14 CN disclosed
WO-2022112352-A1 HETEROCYCLE DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2022-06-02 WO disclosed