Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 16/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26225819 | 1.00 | PTGES (0.45) | PTGESPTGS2P2RX7ROCK2BLM | |
| SCHEMBL26225667 | 1.00 | PTGES (0.45) | PTGESPTGS2P2RX7ROCK2BLM | |
| SCHEMBL26225814 | 1.00 | PTGES (0.45) | PTGESPTGS2P2RX7ROCK2BLM | |
| SCHEMBL29630766 | 1.00 | PTGES (0.45) | PTGESPTGS2P2RX7ROCK2BLM | |
| SCHEMBL29630708 | 1.00 | PTGES (0.45) | PTGESPTGS2P2RX7ROCK2BLM | |
| SCHEMBL26225679 | 0.91 | PTGES (0.52) | PTGESPTGS2 | |
| SCHEMBL29630868 | 0.91 | PTGES (0.52) | PTGESPTGS2 | |
| SCHEMBL26225669 | 0.89 | PTGES (0.43) | PTGESPTGS2ROCK2BLMKMT2A | |
| SCHEMBL24473755 | 0.88 | PTGES (0.52) | PTGESPTGS2P2RX7BLMKMT2A | |
| SCHEMBL26228181 | 0.88 | PTGES (0.52) | PTGESPTGS2P2RX7BLMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251623-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-10-04 | — | — | EP | claimed |
| WO-2022112140-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-02 | — | — | WO | claimed |
| EP-4251623-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-10-04 | — | — | EP | disclosed |
| CN-116457352-A | Aryloxazolo spiro derivatives for the treatment and prophylaxis of hepatitis b virus infection | 豪夫迈·罗氏有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022112140-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-02 | — | — | WO | disclosed |