Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 19/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26225711 | 1.00 | PTGES (0.46) | PTGESPTGS2HDAC4 | |
| SCHEMBL24473914 | 0.91 | PTGES (0.50) | PTGESPTGS2HDAC4 | |
| SCHEMBL26225706 | 0.90 | PTGES (0.47) | PTGESPTGS2HDAC4 | |
| SCHEMBL29895625 | 0.90 | PTGES (0.47) | PTGESPTGS2HDAC4 | |
| SCHEMBL29630913 | 0.89 | PTGES (0.50) | PTGESPTGS2 | |
| SCHEMBL26225779 | 0.89 | PTGES (0.50) | PTGESPTGS2 | |
| SCHEMBL26225713 | 0.89 | PTGES (0.50) | PTGESPTGS2 | |
| SCHEMBL26225689 | 0.87 | PTGES (0.46) | PTGESPTGS2HDAC4 | |
| SCHEMBL29630851 | 0.84 | PTGES (0.44) | PTGESPTGS2HDAC4 | |
| SCHEMBL26225694 | 0.84 | PTGES (0.44) | PTGESPTGS2HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4251623-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-10-04 | — | — | EP | claimed |
| WO-2022112140-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-02 | — | — | WO | claimed |
| EP-4251623-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-10-04 | — | — | EP | disclosed |
| WO-2022112140-A1 | ARYLOXAZOLO SPIRAL RING DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2022-06-02 | — | — | WO | disclosed |