Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 8/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24360046 | 1.00 | MCHR1 (0.48) | MCHR1ADRA2ARAF1EPHX2L3MBTL1 | |
| SCHEMBL24494407 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL29632199 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL24360028 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL29632072 | 0.91 | MCHR1 (0.47) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL30540312 | 0.91 | MCHR1 (0.51) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL24360165 | 0.91 | MCHR1 (0.48) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL29632110 | 0.91 | MCHR1 (0.48) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL24360164 | 0.91 | MCHR1 (0.48) | MCHR1ADRA2AL3MBTL1NPC1RAB9A | |
| SCHEMBL24360067 | 0.90 | GAA (0.47) | MCHR1ADRA2ARAF1EPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232042-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2022087083-A1 | MODULATORS OF MAS-RELATED G-PROTEIN RECEPTOR X2 AND RELATED PRODUCTS AND THEIR USE | ESCIENT PHARMACEUTICALS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |