Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 7/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.39 |
| ▸ | WNT1 | P04628 | 3/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | BTK | Q06187 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21174154 | 1.00 | MET (0.45) | METGSK3BDYRK1AWNT1KIT | |
| SCHEMBL21174281 | 0.91 | MET (0.50) | METKITBTKMAPK1PDPK1 | |
| SCHEMBL21174231 | 0.90 | MET (0.49) | METDYRK1AKITBTKMAPK1 | |
| SCHEMBL21174064 | 0.90 | MET (0.49) | METDYRK1AKITBTKMAPK1 | |
| SCHEMBL30751054 | 0.90 | MET (0.34) | METGSK3BDYRK1AKITBTK | |
| SCHEMBL27376466 | 0.90 | MET (0.34) | METGSK3BDYRK1AKITBTK | |
| SCHEMBL30751078 | 0.89 | ALK (0.40) | METGSK3BDYRK1ABTKMAPK1 | |
| SCHEMBL27378184 | 0.89 | ALK (0.40) | METGSK3BDYRK1ABTKMAPK1 | |
| SCHEMBL30751395 | 0.88 | MET (0.46) | METGSK3BDYRK1AKITBTK | |
| SCHEMBL30751474 | 0.88 | MET (0.47) | METGSK3BDYRK1AWNT1KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3514149-B1 | HETEROCYCLIC AMIDE COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2022-05-18 | — | — | EP | disclosed |