Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.54 |
| ▸ | NAMPT | P43490 | 8/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23304792 | 0.93 | GPR119 (0.50) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL22520476 | 0.91 | GPR119 (0.52) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL19839298 | 0.91 | GPR119 (0.61) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL19839814 | 0.87 | KMT2A (0.50) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL24408866 | 0.84 | GPR119 (0.48) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL18572347 | 0.84 | CCNC (0.50) | GPR119NAMPTCCNCCDK8HASPIN | |
| SCHEMBL31094899 | 0.83 | GPR119 (0.54) | GPR119HRH3 | |
| SCHEMBL17848653 | 0.83 | GPR119 (0.54) | GPR119HRH3 | |
| SCHEMBL24409036 | 0.83 | GPR119 (0.50) | GPR119NAMPTHRH3CCNCCDK8 | |
| SCHEMBL18572366 | 0.81 | CCNC (0.47) | GPR119NAMPTCCNCCDK8HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022095971-A1 | SPIRO HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海医药集团股份有限公司 | 2022-05-12 | — | — | WO | disclosed |