Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.81 |
| ▸ | JAK2 | O60674 | 9/20 | 0.66 |
| ▸ | JAK1 | P23458 | 1/20 | 0.66 |
| ▸ | TYK2 | P29597 | 1/20 | 0.66 |
| ▸ | JAK3 | P52333 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14717552 | 1.00 | SYK (0.81) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14716664 | 0.91 | SYK (0.68) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL29635046 | 0.91 | SYK (0.68) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30604786 | 0.90 | SYK (0.80) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL29635054 | 0.90 | SYK (0.80) | SYKJAK2 | |
| SCHEMBL14716715 | 0.90 | SYK (0.80) | SYKJAK2 | |
| SCHEMBL29635165 | 0.90 | SYK (0.83) | SYKJAK2 | |
| SCHEMBL14717018 | 0.90 | SYK (0.83) | SYKJAK2 | |
| SCHEMBL30604962 | 0.89 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 | |
| SCHEMBL14717136 | 0.89 | SYK (1.00) | SYKJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | claimed |
| EP-4327886-A2 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | Libertas Bio, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3392252-B1 | PYRIMIDO- PYRIDAZINONE COMPOUNDS AND USE THEREOF | LIBERTAS BIO INC (US) | 2023-10-04 | — | — | EP | disclosed |
| CN-108707151-B | Pyrimido-pyridazinone compounds and uses thereof | 阿萨纳生物科技有限责任公司 | 2022-06-03 | — | — | CN | disclosed |