Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20129909 | 1.00 | PDE1B (0.56) | PDE1BKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL21117374 | 0.82 | PDE4B (0.64) | KDM4EALDH1A1HTTPDE4BNPSR1 | |
| SCHEMBL31008705 | 0.81 | GRIN1 (0.59) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23723051 | 0.79 | PDE1B (0.61) | PDE1BKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL29722691 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23930353 | 0.79 | MEN1 (0.54) | PDE1BKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL27193449 | 0.78 | PDE1B (0.66) | PDE1BKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL31533729 | 0.78 | PDE1B (0.66) | PDE1BKDM4EALDH1A1MAPTMEN1 | |
| SCHEMBL25241170 | 0.77 | PDE1B (0.57) | PDE1BALDH1A1HPGD | |
| SCHEMBL30287089 | 0.77 | PDE1B (0.72) | PDE1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989164-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2024-08-13 | — | — | CN | disclosed |
| CN-114989164-A | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-110062761-B | Substituted 1H-imidazo [4,5-b ] pyridin-2 (3H) -ones and uses thereof | 詹森药业有限公司 | 2022-05-13 | — | — | CN | disclosed |