Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466772 | 0.98 | UHRF1 (0.46) | UHRF1CCR1CCR5CCR8NOS1 | |
| Bromide SCHEMBL27973630 | 0.96 | UHRF1 (0.45) | UHRF1CCR1CCR5CCR8NOS1 | |
| SCHEMBL6472039 | 0.91 | UHRF1 (0.61) | UHRF1CCR1CCR5CCR8NOS1 | |
| Diethylamine SCHEMBL6638505 | 0.88 | KMT2A (0.42) | UHRF1CCR1CCR5CCR8NOS1 | |
| SCHEMBL8565055 | 0.86 | UHRF1 (0.43) | UHRF1CCR1CCR5CCR8NOS1 | |
| SCHEMBL20099912 | 0.85 | UHRF1 (0.42) | UHRF1CCR1CCR5CCR8NOS1 | |
| SCHEMBL8569721 | 0.83 | UHRF1 (0.41) | UHRF1CCR1CCR5CCR8NOS1 | |
| Bromide SCHEMBL38664578 | 0.83 | UHRF1 (0.41) | UHRF1CCR1CCR5CCR8NOS1 | |
| SCHEMBL510182 | 0.81 | — | — | |
| SCHEMBL7893402 | 0.79 | KDM4E (0.55) | UHRF1CCR1CCR5CCR8NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111072632-B | Fluorescent probe for displaying two states of cell membrane potential by using fluorescent image and application thereof | 山东大学 | 2022-03-22 | — | — | CN | disclosed |