Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 14/20 | 0.76 |
| ▸ | EHMT1 | Q9H9B1 | 13/20 | 0.76 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.60 |
| ▸ | EGFR | P00533 | 3/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8526894 | 1.00 | EHMT2 (0.76) | EHMT2EHMT1DNMT1EGFRFGFR2 | |
| SCHEMBL2748129 | 0.99 | EHMT2 (0.74) | EHMT2EHMT1DNMT1EGFRFGFR2 | |
| Hydrochloric Acid SCHEMBL6433786 | 0.99 | EHMT2 (0.74) | EHMT2EHMT1DNMT1EGFRFGFR2 | |
| SCHEMBL2746706 | 0.94 | EHMT2 (0.67) | EHMT2EHMT1DNMT1EGFRFGFR1 | |
| SCHEMBL2152700 | 0.92 | EHMT2 (0.64) | EHMT2EHMT1EGFRFGFR1FLT1 | |
| SCHEMBL903068 | 0.90 | EGFR (0.64) | EHMT2EHMT1EGFRFGFR1FLT1 | |
| SCHEMBL2152791 | 0.90 | EHMT2 (0.62) | EHMT2EHMT1EGFR | |
| SCHEMBL5097860 | 0.90 | EGFR (0.64) | EHMT2EHMT1EGFRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL6432089 | 0.89 | EGFR (0.62) | EHMT2EHMT1EGFRFGFR1FLT1 | |
| SCHEMBL16707263 | 0.86 | EHMT2 (0.56) | EHMT2EHMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114667145-A | Molecules that bind to TDP-43 for the treatment of amyotrophic lateral sclerosis and related disorders | 拜尔哈文制药股份有限公司 | 2022-06-24 | — | — | CN | disclosed |