Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.64 |
| ▸ | EHMT1 | Q9H9B1 | 9/20 | 0.64 |
| ▸ | AXL | P30530 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | WEE2 | P0C1S8 | 2/20 | 0.56 |
| ▸ | WEE1 | P30291 | 2/20 | 0.56 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | FYN | P06241 | 2/20 | 0.56 |
| ▸ | SRC | P12931 | 2/20 | 0.56 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | STK25 | O00506 | 1/20 | 0.55 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.55 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | CASK | O14936 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27006970 | 0.94 | EGFR (0.59) | EHMT2EHMT1AXLEGFRWEE2 | |
| SCHEMBL29636829 | 0.92 | EHMT2 (0.76) | EHMT2EHMT1EGFRKDRFGFR1 | |
| SCHEMBL8526894 | 0.92 | EHMT2 (0.76) | EHMT2EHMT1EGFRKDRFGFR1 | |
| Hydrochloric Acid SCHEMBL6433786 | 0.91 | EHMT2 (0.74) | EHMT2EHMT1EGFRKDRFGFR1 | |
| SCHEMBL2748129 | 0.91 | EHMT2 (0.74) | EHMT2EHMT1EGFRKDRSRC | |
| SCHEMBL5097860 | 0.89 | EGFR (0.64) | EHMT2EHMT1AXLEGFRKDR | |
| SCHEMBL903068 | 0.89 | EGFR (0.64) | EHMT2EHMT1AXLEGFRKDR | |
| SCHEMBL2152791 | 0.89 | EHMT2 (0.62) | EHMT2EHMT1EGFRSRCERBB2 | |
| Hydrochloric Acid SCHEMBL6432089 | 0.88 | EGFR (0.62) | EHMT2EHMT1AXLEGFRKDR | |
| SCHEMBL2746706 | 0.86 | EHMT2 (0.67) | EHMT2EHMT1EGFRKDRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314232-B2 | Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide | GLAXOSMITHKLINE LLC (US) | 2012-11-20 | — | — | US | disclosed |
| EP-2339918-A1 | PREPARATION OF A QUINOLINYLOXYDIPHENYLCYCLOPROPANEDICARBOXAMIDE | GlaxoSmithKline LLC (US) | 2011-07-06 | — | — | EP | disclosed |
| US-20100081805-A1 | Preparation of a Quinolinyloxydiphenylcyclopropanedicarboxamide | EXELIXIS, INC. | 2010-04-01 | — | — | US | disclosed |
| WO-2010036831-A1 | PREPARATION OF A QUINOLINYLOXYDIPHENYLCYCLOPROPANEDICARBOXAMIDE | GLAXOSMITHKLINE LLC (US) | 2010-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100081805-A1 | Preparation of a Quinolinyloxydiphenylcyclopropanedicarboxamide | QDPR, CBR3, NQO2 | EHMT2 3821/4885EHMT1 4297/4885AXL 3026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.