Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | GALR2 | O43603 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.49 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | TXNRD1 | Q16881 | 4/20 | 0.43 |
| ▸ | GSR | P00390 | 3/20 | 0.43 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PGK1 | P00558 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242494 | 1.00 | MAPT (0.59) | MAPTHTTPOLBGALR2LMNA | |
| SCHEMBL27211667 | 0.81 | MAPT (0.68) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL21522837 | 0.81 | MAPT (0.55) | MAPTHTTPOLBGALR2LMNA | |
| SCHEMBL10697630 | 0.81 | MAPT (0.55) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL5091991 | 0.81 | MAPT (0.55) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL1978817 | 0.81 | MAPT (0.67) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL30154422 | 0.81 | MAPT (0.67) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL1431713 | 0.80 | MAPT (0.54) | MAPTHTTPOLBGALR2LMNA | |
| SCHEMBL5099519 | 0.80 | MAPT (0.61) | MAPTHTTPOLBFGFR4MERTK | |
| SCHEMBL28835842 | 0.79 | MAPT (0.56) | MAPTHTTPOLBGALR2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4228632-A2 | REV-ERB AGONISTS | Saint Louis University (US) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022093552-A9 | REV-ERB AGONISTS | Saint Louis Univeristy (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022093552-A2 | REV-ERB AGONISTS | Saint Louis Univeristy (US) | 2022-05-05 | — | — | WO | disclosed |