Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | GUCY1A1 | Q02108 | 14/20 | 0.41 |
| ▸ | GUCY1B1 | Q02153 | 14/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23162009 | 1.00 | ADORA3 (0.43) | ADORA3KCNH2GUCY1A1GUCY1B1ALDH1A1 | |
| SCHEMBL29637229 | 0.98 | ADORA3 (0.43) | ADORA3KCNH2GUCY1A1GUCY1B1ALDH1A1 | |
| SCHEMBL23162029 | 0.98 | ADORA3 (0.43) | ADORA3KCNH2GUCY1A1GUCY1B1ALDH1A1 | |
| SCHEMBL29637227 | 0.88 | ADORA3 (0.47) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL23162020 | 0.88 | ADORA3 (0.47) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL23161979 | 0.88 | ADORA3 (0.42) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL29637233 | 0.88 | ADORA3 (0.42) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL23162002 | 0.88 | ADORA3 (0.44) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL29637226 | 0.88 | ADORA3 (0.44) | ADORA3KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL23161973 | 0.86 | ADORA3 (0.43) | ADORA3KCNH2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3609883-B1 | FLUORINE-SUBSTITUTED INDAZOLE COMPOUNDS AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2022-06-29 | — | — | EP | disclosed |