SCHEMBL29637731

SCHEMBL29637731

Cc1ncc(F)c(Nc2n[nH]c3c2CNC3(C)C)n1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRKCB P05771 19/20 0.53
PAK4 O96013 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21179291 1.00 PRKCB (0.53) PRKCBPAK4
SCHEMBL22206298 0.80 PRKCB (0.75) PRKCBPAK4
SCHEMBL22206299 0.78 PRKCB (0.62) PRKCBPAK4
SCHEMBL22217131 0.76 PRKCB (0.71) PRKCBPAK4
SCHEMBL3327623 0.72 PRKCB (0.66) PRKCBPAK4
SCHEMBL3327434 0.70 PRKCB (1.00) PRKCBPAK4
SCHEMBL3327770 0.67 PRKCB (1.00) PRKCB
SCHEMBL1367931 0.67 PAK4 (1.00) PAK4
SCHEMBL7014150 0.65 PRKCB (0.54) PRKCBPAK4
SCHEMBL21143486 0.65 PRKCB (0.45) PRKCBPAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022261214-A1 COMPOSITIONS COMPRISING PKC-BETA INHIBITORS AND PROCESSES FOR THE PREPARATION THEREOF MINGSIGHT PHARMACEUTICALS, INC. (US) 2022-12-15 WO disclosed
CN-115381832-A Treatment of cancer 深圳明赛瑞霖药业有限公司 2022-11-25 CN disclosed
US-20220202815-A1 TREATMENT OF CANCER MINGSIGHT PHARMACEUTICALS, INC. 2022-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220202815-A1 TREATMENT OF CANCER PRKACB, PRKDC, PRKCH PRKCB 4/4885PAK4 264/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.