Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.67 |
| ▸ | CDK2 | P24941 | 2/20 | 0.67 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.67 |
| ▸ | FLT3 | P36888 | 7/20 | 0.65 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.62 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14448964 | 0.86 | MDM2 (0.68) | NPC1MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL5478629 | 0.86 | MDM2 (0.68) | NPC1MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL5478628 | 0.86 | MDM2 (0.68) | NPC1MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL5469888 | 0.86 | MDM2 (0.74) | NPC1MEN1KMT2AFLT3MDM2 | |
| SCHEMBL5469894 | 0.86 | MDM2 (0.74) | NPC1MEN1KMT2AFLT3MDM2 | |
| SCHEMBL7136252 | 0.86 | NPC1 (0.72) | NPC1MEN1KMT2ACCNE1CDK2 | |
| SCHEMBL5469692 | 0.85 | NPC1 (1.00) | NPC1CCNE1CDK2FLT3MDM2 | |
| SCHEMBL5469690 | 0.85 | NPC1 (1.00) | NPC1CCNE1CDK2FLT3MDM2 | |
| SCHEMBL16442345 | 0.85 | NPC1 (1.00) | NPC1CCNE1CDK2FLT3MDM2 | |
| SCHEMBL29367529 | 0.85 | NPC1 (1.00) | NPC1CCNE1CDK2FLT3MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111116452-B | Indolone derivatives with alpha-glucosidase inhibitory activity as well as preparation method and application thereof | 五邑大学 | 2022-05-03 | — | — | CN | disclosed |