Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | APP | P05067 | 2/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | BLM | P54132 | 2/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5368659 | 0.89 | NPC1 (0.57) | NPC1MDM2MEN1KMT2AMAPT | |
| SCHEMBL5369981 | 0.87 | NPC1 (0.54) | NPC1MDM2MEN1KMT2AMAPT | |
| SCHEMBL29638296 | 0.86 | NPC1 (0.74) | NPC1MDM2MEN1KMT2ACCNE1 | |
| SCHEMBL5363455 | 0.86 | MAPT (0.58) | NPC1MDM2MEN1KMT2AMAPT | |
| SCHEMBL5368424 | 0.85 | MDM2 (0.61) | NPC1MDM2MAPTAPPCSNK1D | |
| SCHEMBL5358059 | 0.85 | MDM2 (0.75) | NPC1MDM2MAPTAPPCSNK1D | |
| SCHEMBL5469894 | 0.85 | MDM2 (0.74) | NPC1MDM2MEN1KMT2AEGFR | |
| SCHEMBL5469888 | 0.85 | MDM2 (0.74) | NPC1MDM2MEN1KMT2AEGFR | |
| SCHEMBL5469690 | 0.84 | NPC1 (1.00) | NPC1MDM2MAPTCSNK1DCSNK1A1 | |
| SCHEMBL16442345 | 0.84 | NPC1 (1.00) | NPC1MDM2MAPTCSNK1DCSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6506763-B2 | Useful in prevention and treatment of protein kinase related disorders such as cancer | SUGEN, INC. | 2003-01-14 | — | — | US | disclosed |