SCHEMBL29639155

SCHEMBL29639155

CC(C)(C)[Si](C)(C)Oc1cccc(NC(=O)c2ccc3ncccc3c2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.57
NPC1 O15118 7/20 0.57
CASP3 P42574 1/20 0.55
SENP8 Q96LD8 1/20 0.55
SENP7 Q9BQF6 1/20 0.55
SENP6 Q9GZR1 1/20 0.55
POLB P06746 1/20 0.55
PLK1 P53350 1/20 0.52
PABPC1 P11940 1/20 0.52
BRAF P15056 1/20 0.52
BLK P51451 1/20 0.49
BTK Q06187 1/20 0.49
HSF1 Q00613 1/20 0.49
ALOX15 P16050 1/20 0.49
HTT P42858 1/20 0.49
ALDH1A1 P00352 2/20 0.48
GAA P10253 2/20 0.48
MAPT P10636 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
HDAC1 Q13547 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28741186 1.00 RAB9A (0.57) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL29639217 0.88 RAB9A (0.56) RAB9ANPC1POLBBRAFHTT
SCHEMBL28741236 0.88 RAB9A (0.56) RAB9ANPC1POLBBRAFHTT
SCHEMBL13702121 0.81 TSHR (0.63) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL29639130 0.80 RAB9A (0.57) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL28741148 0.80 RAB9A (0.57) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL1681165 0.78 NR1H4 (0.62) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL28741198 0.78 RAB9A (0.55) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL29639177 0.78 GMPS (0.61) RAB9ANPC1CASP3SENP8SENP7
SCHEMBL29639190 0.78 RAB9A (0.55) RAB9ANPC1CASP3SENP8SENP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114436978-B Antifungal compound and application thereof 中国人民解放军海军军医大学 2024-06-18 CN disclosed
CN-114436978-A Antifungal compound and application 中国人民解放军海军军医大学 2022-05-06 CN disclosed