Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 6/20 | 0.79 |
| ▸ | KDM2A | Q9Y2K7 | 6/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.79 |
| ▸ | KDM5C | P41229 | 4/20 | 0.79 |
| ▸ | EGLN1 | Q9GZT9 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.53 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.53 |
| ▸ | KDM6B | O15054 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.43 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960529 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL26106890 | 0.86 | PHF8 (0.94) | PHF8KDM2AKDM4EKDM5CEGLN1 | |
| SCHEMBL220535 | 0.84 | — | — | |
| SCHEMBL1111110 | 0.81 | — | — | |
| SCHEMBL959046 | 0.78 | KDM4E (0.71) | PHF8KDM2AKDM4EKDM5CLMNA | |
| SCHEMBL141621 | 0.78 | KDM4E (0.71) | PHF8KDM2AKDM4EKDM5CLMNA | |
| Adipic Acid SCHEMBL28086908 | 0.78 | KDM4E (0.71) | PHF8KDM2AKDM4EKDM5CLMNA | |
| Adipic Acid SCHEMBL28675238 | 0.78 | KDM4E (0.71) | PHF8KDM2AKDM4EKDM5CLMNA | |
| Methyl Alcohol SCHEMBL28827180 | 0.78 | CTSD (0.55) | PHF8KDM2AKDM4EKDM5CLMNA | |
| SCHEMBL994875 | 0.76 | KDM4E (0.68) | PHF8KDM2AKDM4EKDM5CLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022137906-A1 | AQUEOUS POLYURETHANE RESIN, SURFACE TREATMENT AGENT, AND LEATHER SUBJECTED TO SURFACE TREATMENT EMPLOYING SAME | 日華化学株式会社 | 2022-06-30 | — | — | WO | disclosed |