Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.46 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29627927 | 0.91 | ROCK2 (0.46) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29627828 | 0.90 | ROCK2 (0.58) | ROCK2ROCK1 | |
| SCHEMBL29627716 | 0.88 | ROCK2 (0.46) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29627973 | 0.88 | ROCK2 (0.37) | ROCK2ROCK1SMO | |
| SCHEMBL29627761 | 0.87 | ROCK2 (0.56) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29627717 | 0.87 | ROCK2 (0.34) | ROCK2ROCK1 | |
| SCHEMBL29908253 | 0.86 | ROCK2 (0.49) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29627719 | 0.86 | ROCK2 (0.53) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29627940 | 0.85 | ROCK2 (0.48) | ROCK2ROCK1TMEM97 | |
| SCHEMBL29640423 | 0.85 | ROCK2 (0.56) | ROCK2ROCK1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114502163-A | Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2022-05-13 | — | — | CN | claimed |
| CN-114502163-A | Ethynylheterocycles as RHO-related coiled coil kinase (ROCK) inhibitors | 安吉昂生物医药公司 | 2022-05-13 | — | — | CN | disclosed |