Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | BCL2 | P10415 | 3/20 | 0.46 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376696 | 0.88 | F2 (0.45) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL2965712 | 0.85 | BCL2L1 (0.46) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL2948234 | 0.83 | USP2 (0.46) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL376939 | 0.82 | MAPKAPK2 (0.45) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL2942401 | 0.78 | USP2 (0.50) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL19424347 | 0.78 | BCL2L1 (0.58) | BCL2BCL2L1 | |
| SCHEMBL1540486 | 0.77 | BCL2 (0.41) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL1540484 | 0.77 | BCL2 (0.41) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL1540968 | 0.77 | MAPKAPK2 (0.38) | USP2ALDH1A1MAPK1CYP3A4TP53 | |
| SCHEMBL1540965 | 0.77 | MAPKAPK2 (0.43) | USP2ALDH1A1MAPK1CYP3A4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888543-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| US-7777076-B2 | Macrocyclic inhibitors of BCL proteins | ABBOTT LABORATORIES (US) | 2010-08-17 | — | — | US | disclosed |
| US-20080194691-A1 | Apoptosis Promoters | ABBOTT LABORATORIES (US) | 2008-08-14 | — | — | US | disclosed |
| EP-1888543-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006127364-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194691-A1 | Apoptosis Promoters | BAX, BCL2, BCOR | USP2 2188/4885ALDH1A1 2433/4885MAPK1 2240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.