Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL376911 | 0.90 | PARP14 (0.45) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL376530 | 0.87 | ALDH1A1 (0.44) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL386110 | 0.86 | F2 (0.47) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL2964098 | 0.85 | USP2 (0.47) | BCL2L1BCL2MEN1KMT2AUSP2 | |
| SCHEMBL2948234 | 0.84 | USP2 (0.46) | BCL2L1BCL2MEN1KMT2AMAPT | |
| SCHEMBL376529 | 0.84 | BCL2L1 (0.40) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL13503798 | 0.83 | ALDH1A1 (0.42) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL4639085 | 0.82 | GAA (0.41) | MEN1KMT2AALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL2962385 | 0.81 | KMT2A (0.38) | BCL2L1BCL2MEN1KMT2AHTT | |
| SCHEMBL376891 | 0.81 | KDM4E (0.45) | BCL2L1BCL2MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888543-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| US-7777076-B2 | Macrocyclic inhibitors of BCL proteins | ABBOTT LABORATORIES (US) | 2010-08-17 | — | — | US | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES | 2010-02-11 | — | — | US | disclosed |
| US-7585858-B2 | N-sulfonylcarboximidamide apoptosis promoters | ABBOTT LABORATORIES (US) | 2009-09-08 | — | — | US | disclosed |
| US-20080194691-A1 | Apoptosis Promoters | ABBOTT LABORATORIES (US) | 2008-08-14 | — | — | US | disclosed |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | ABBVIE INC. | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194691-A1 | Apoptosis Promoters | BAX, BCL2, BCOR | BCL2L1 6/4885BCL2 2/4885MEN1 2677/4885 |
| US-20100035879-A1 | N-SULFONYLCARBOXIMIDAMIDE APOPTOSIS PROMOTERS | BAX, BCL2, BAD | BCL2L1 18/4885BCL2 2/4885MEN1 4383/4885 |
| US-20050272744-A1 | N-sulfonylcarboximidamide apoptosis promoters | BAX, BCL2, BAD | BCL2L1 18/4885BCL2 2/4885MEN1 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.