⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8539742 | 0.92 | — | — | |
| SCHEMBL29855730 | 0.65 | ALDH1A1 (0.46) | — | |
| SCHEMBL10585911 | 0.63 | — | — | |
| SCHEMBL65251 | 0.63 | — | — | |
| SCHEMBL4985795 | 0.61 | — | — | |
| SCHEMBL6347518 | 0.61 | ALDH1A1 (0.42) | — | |
| SCHEMBL64122 | 0.61 | — | — | |
| SCHEMBL7738645 | 0.61 | ALDH1A1 (0.42) | — | |
| SCHEMBL6948810 | 0.60 | — | — | |
| SCHEMBL2872785 | 0.59 | ALDH1A1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776349-A2 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-25 | — | — | EP | claimed |
| WO-2006017836-A2 | 2-AMINO-QUINAZOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-02-16 | — | — | WO | claimed |
| EP-0286364-B1 | Substituted Di-t-Butylphenols | RIKER LABORATORIES INC (US) | 1994-07-13 | — | — | EP | claimed |
| US-5049572-A | Leukotriene biosynthesis inhibitors | RIKER LABORATORIES, INC. (US) | 1991-09-17 | — | — | US | claimed |
| EP-0286364-A2 | Substituted Di-t-Butylphenols | RIKER LABORATORIES, INC. (US) | 1988-10-12 | — | — | EP | claimed |
| CN-107229195-B | Electrophotographic photoreceptor, image forming apparatus using the same, and image forming method | 柯尼卡美能达株式会社 | 2020-08-18 | — | — | CN | disclosed |
| US-7776882-B2 | 2-amino-3,4-dihydro-quinoline derivatives useful as inhibitors of β-secretase (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2010-08-17 | — | — | US | disclosed |
| US-20080194624-A1 | 2-AMINO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-14 | — | — | US | disclosed |
| US-20070232642-A1 | 2-AMINO-3,4-DIHYDRO-QUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) | JANSSEN PHARMACEUTICA NV (BE) | 2007-10-04 | — | — | US | disclosed |
| EP-0923562-A1 | SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS | BAYER AG (DE) | 1999-06-23 | — | — | EP | disclosed |
| EP-0842155-A1 | SUBSTITUTED AMINOURACILS | BAYER AG (DE) | 1998-05-20 | — | — | EP | disclosed |
| WO-1998006706-A1 | SUBSTITUTED P-TRIFLUOROMETHYLPHENYLURACILS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-02-19 | — | — | WO | disclosed |
| WO-1997005116-A1 | SUBSTITUTED AMINOURACILS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-13 | — | — | WO | disclosed |
| EP-0286364-B1 | Substituted Di-t-Butylphenols | RIKER LABORATORIES INC (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5103037-A | Inhibitors of leukotriene biosynthesis; antiallergens | RIKER LABORATORIES, INC. (US) | 1992-04-07 | — | — | US | disclosed |
| US-5049572-A | Leukotriene biosynthesis inhibitors | RIKER LABORATORIES, INC. (US) | 1991-09-17 | — | — | US | disclosed |
| EP-0286364-A2 | Substituted Di-t-Butylphenols | RIKER LABORATORIES, INC. (US) | 1988-10-12 | — | — | EP | disclosed |