Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.66 |
| ▸ | CA1 | P00915 | 8/20 | 0.36 |
| ▸ | CA2 | P00918 | 8/20 | 0.36 |
| ▸ | CA12 | O43570 | 6/20 | 0.36 |
| ▸ | CA9 | Q16790 | 6/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19015270 | 1.00 | COMT (0.66) | COMTCA1CA2CA12CA9 | |
| SCHEMBL29642781 | 0.91 | COMT (0.58) | COMTCA1CA2CA12CA9 | |
| SCHEMBL20590973 | 0.91 | COMT (0.58) | COMTCA1CA2CA12CA9 | |
| SCHEMBL18986811 | 0.88 | COMT (0.72) | COMT | |
| SCHEMBL31514946 | 0.87 | COMT (0.47) | COMTCA1CA2CA12CA9 | |
| SCHEMBL31514934 | 0.87 | COMT (0.47) | COMTCA1CA2CA12CA9 | |
| SCHEMBL29642891 | 0.83 | COMT (0.79) | COMTMAOAMAOB | |
| SCHEMBL18987105 | 0.83 | COMT (0.79) | COMTMAOAMAOB | |
| SCHEMBL18987117 | 0.81 | COMT (1.00) | COMT | |
| SCHEMBL31514945 | 0.81 | COMT (1.00) | COMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | claimed |
| CN-108698984-B | Bicyclic compounds for use as medicaments, in particular for the treatment of parkinson's disease | H·科斯特 | 2022-05-10 | — | — | CN | disclosed |