Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 7/20 | 0.79 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.32 |
| ▸ | MC4R | P32245 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.32 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18987105 | 1.00 | COMT (0.79) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18987018 | 0.90 | COMT (0.69) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29642820 | 0.90 | COMT (0.69) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31514945 | 0.89 | COMT (1.00) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18987117 | 0.89 | COMT (1.00) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18986811 | 0.87 | COMT (0.72) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31514942 | 0.86 | COMT (0.76) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18987016 | 0.86 | COMT (0.76) | COMTHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31514938 | 0.84 | COMT (0.55) | COMTHPGDCYP1A2FTOMC4R | |
| SCHEMBL29642900 | 0.84 | COMT (0.70) | COMTHPGDNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390351-B1 | NOVEL BICYCLIC-COMPOUNDS FOR USE AS A MEDICAMENT, IN PARTICULAR FOR TREATMENT OF PARKINSON'S DISEASE | KOESTER HUBERT (DE) | 2025-02-26 | — | — | EP | claimed |
| CN-108698984-B | Bicyclic compounds for use as medicaments, in particular for the treatment of parkinson's disease | H·科斯特 | 2022-05-10 | — | — | CN | disclosed |