Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 11/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643035 | 0.75 | MEN1 (0.56) | RPS6KB1AURKAMEN1KMT2AJAK2 | |
| SCHEMBL29638725 | 0.73 | RPS6KB1 (0.46) | RPS6KB1AURKAAKT1JAK2JAK1 | |
| SCHEMBL20621843 | 0.72 | RPS6KB1 (0.43) | RPS6KB1AURKAMEN1KMT2AJAK2 | |
| SCHEMBL6763097 | 0.71 | RPS6KB1 (0.38) | RPS6KB1AKT1 | |
| SCHEMBL7174336 | 0.68 | AURKA (0.40) | RPS6KB1AURKAMEN1KMT2AJAK2 | |
| SCHEMBL22732067 | 0.67 | TYK2 (0.46) | RPS6KB1AURKAJAK2JAK1TYK2 | |
| SCHEMBL5961431 | 0.67 | PDE4A (0.50) | KDM4ESMN1; SMN2 | |
| SCHEMBL30453817 | 0.67 | IRAK4 (0.44) | — | |
| SCHEMBL22732206 | 0.66 | TYK2 (0.47) | RPS6KB1AURKAJAK2JAK1TYK2 | |
| SCHEMBL30609368 | 0.65 | RPS6KB1 (0.44) | RPS6KB1AKT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4255911-A1 | BICYCLIC DERIVATIVES | Elanco Tiergesundheit AG (CH) | 2023-10-11 | — | — | EP | disclosed |
| WO-2022117783-A1 | BICYCLIC DERIVATIVES | ELANCO TIERGESUNDHEIT AG (CH) | 2022-06-09 | — | — | WO | disclosed |