Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.82 |
| ▸ | BRAF | P15056 | 8/20 | 0.81 |
| ▸ | KDR | P35968 | 7/20 | 0.81 |
| ▸ | RET | P07949 | 3/20 | 0.81 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.81 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.81 |
| ▸ | ABL1 | P00519 | 2/20 | 0.81 |
| ▸ | HTR1A | P08908 | 2/20 | 0.81 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.81 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.81 |
| ▸ | KIT | P10721 | 2/20 | 0.81 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.81 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.81 |
| ▸ | FLT1 | P17948 | 2/20 | 0.81 |
| ▸ | MAOA | P21397 | 2/20 | 0.81 |
| ▸ | EPHA1 | P21709 | 2/20 | 0.81 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.81 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.81 |
| ▸ | TTK | P33981 | 2/20 | 0.81 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL432444 | 1.00 | RAF1 (0.82) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL4609009 | 0.92 | BRAF (0.82) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL4238109 | 0.91 | RAF1 (0.82) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL29918250 | 0.91 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL548133 | 0.91 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL12333608 | 0.90 | RAF1 (0.82) | RAF1BRAFKDRRETRIPK2 | |
| SCHEMBL22627130 | 0.90 | RAF1 (0.85) | RAF1BRAFKDRRETRIPK2 | |
| Regorafenib SCHEMBL29351376 | 0.89 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| Regorafenib SCHEMBL29349808 | 0.89 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 | |
| Regorafenib SCHEMBL432230 | 0.89 | RAF1 (1.00) | RAF1BRAFKDRRETRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117899212-A | Combination of regorafenib and a PD-1/PD-L1 (2) inhibitor for the treatment of cancer | 拜耳医药保健有限责任公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-110662540-B | Combination of regorafenib and a PD-1/PD-L1 (2) inhibitor for the treatment of cancer | 拜耳医药保健有限责任公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-116392484-A | Coated pharmaceutical composition containing regorafenib | 拜尔健康护理有限责任公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-116392485-A | Coated pharmaceutical composition containing regorafenib | 拜尔健康护理有限责任公司 | 2023-07-07 | — | — | CN | disclosed |
| CN-116392598-A | Coated pharmaceutical composition containing regorafenib | 拜尔健康护理有限责任公司 | 2023-07-07 | — | — | CN | disclosed |
| WO-2022148005-A1 | MEDICINAL SOLID DISPERSION AND PREPARATION METHOD THEREFOR | 湖南南新制药股份有限公司 | 2022-07-14 | — | — | WO | disclosed |
| WO-2022057164-A1 | PREPARATION METHOD FOR MULTI-TARGET ANTI-TUMOR DRUG | 广州南鑫药业有限公司 | 2022-03-24 | — | — | WO | disclosed |