SCHEMBL432444

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL29643339	1.00	RAF1 (0.82)	RAF1BRAFKDRRETRIPK2
	SCHEMBL4609009	0.92	BRAF (0.82)	RAF1BRAFKDRRETRIPK2
	SCHEMBL4238109	0.91	RAF1 (0.82)	RAF1BRAFKDRRETRIPK2
	SCHEMBL29918250	0.91	RAF1 (1.00)	RAF1BRAFKDRRETRIPK2
	SCHEMBL548133	0.91	RAF1 (1.00)	RAF1BRAFKDRRETRIPK2
	SCHEMBL12333608	0.90	RAF1 (0.82)	RAF1BRAFKDRRETRIPK2
	SCHEMBL22627130	0.90	RAF1 (0.85)	RAF1BRAFKDRRETRIPK2
	Regorafenib SCHEMBL29351376	0.89	RAF1 (1.00)	RAF1BRAFKDRRETRIPK2
	Regorafenib SCHEMBL29349808	0.89	RAF1 (1.00)	RAF1BRAFKDRRETRIPK2
	Regorafenib SCHEMBL432230	0.89	RAF1 (1.00)	RAF1BRAFKDRRETRIPK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.