Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 11/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22890466 | 1.00 | LRRK2 (0.51) | LRRK2GAALMNANPSR1ALDH1A1 | |
| SCHEMBL29644137 | 0.83 | LRRK2 (0.48) | LRRK2S1PR2 | |
| SCHEMBL22890818 | 0.83 | LRRK2 (0.48) | LRRK2S1PR2 | |
| SCHEMBL29644092 | 0.78 | LRRK2 (0.55) | LRRK2GAAALDH1A1 | |
| SCHEMBL9423303 | 0.75 | GAA (0.46) | LRRK2GAALMNANPSR1ALDH1A1 | |
| SCHEMBL21616760 | 0.74 | NPSR1 (0.37) | GAALMNANPSR1ALDH1A1 | |
| SCHEMBL22890472 | 0.73 | LRRK2 (0.48) | LRRK2S1PR2 | |
| SCHEMBL29741070 | 0.72 | GAA (0.46) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL3280072 | 0.72 | GAA (0.46) | GAALMNANPSR1ALDH1A1HPGD | |
| SCHEMBL20302398 | 0.71 | CSNK1A1 (0.41) | LRRK2NPSR1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |