Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | AXL | P30530 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467763 | 1.00 | JAK2 (0.53) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL7571940 | 0.84 | PDPK1 (0.53) | JAK2PDPK1GSK3BAXLAURKA | |
| SCHEMBL30860966 | 0.84 | PDPK1 (0.53) | JAK2PDPK1GSK3BAXLAURKA | |
| SCHEMBL118573 | 0.81 | JAK2 (0.64) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL30855645 | 0.79 | PDPK1 (0.68) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL31584704 | 0.76 | MAP2K4 (0.53) | JAK2PDPK1KDM4EMAPTALDH1A1 | |
| SCHEMBL7571499 | 0.76 | GSK3B (0.51) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL4004201 | 0.76 | GSK3B (0.51) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL266855 | 0.76 | GSK3B (0.56) | JAK2PDPK1GSK3BAXLHTR2A | |
| SCHEMBL759158 | 0.76 | GSK3B (0.51) | JAK2PDPK1GSK3BAXLHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3997081-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | Escape Bio, Inc. (US) | 2022-05-18 | — | — | EP | disclosed |