Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1689626 | 1.00 | MAPK1 (0.51) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL16086529 | 0.93 | USP30 (0.50) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL16086784 | 0.93 | USP30 (0.50) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL16086372 | 0.93 | USP30 (0.50) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL13563952 | 0.87 | MAPK1 (0.50) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL2975481 | 0.87 | MAPK1 (0.54) | MAPK1HDAC1HDAC8HDAC6USP30 | |
| SCHEMBL4137234 | 0.86 | MAPK1 (0.47) | MAPK1HDAC1HDAC8HDAC6AVPR1A | |
| SCHEMBL12715964 | 0.86 | AVPR1A (0.50) | MAPK1HDAC1AVPR1ATSHR | |
| SCHEMBL1995317 | 0.84 | NAMPT (0.45) | GPR119POLB | |
| SCHEMBL12715817 | 0.84 | AVPR1A (0.51) | AVPR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113227089-B | Substituted 6-azabenzimidazole compounds as HPK1 inhibitors | 吉利德科学公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-118019735-A | Arylsulfonyl compounds as CCR6 inhibitors | 坎莫森特里克斯公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-117105933-A | Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity | 吉利德科学公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-112969505-B | Substituted 6-azabenzimidazole compounds having HPK1 inhibitory activity | 吉利德科学公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-116113698-A | TRPML modulators | 卡斯玛治疗公司 | 2023-05-12 | — | — | CN | disclosed |
| CN-114591327-B | Indoline piperidine urea TRPV1 antagonism and MOR agonism double-target-point medicine, preparation method and application | 河南大学 | 2023-02-07 | — | — | CN | disclosed |
| CN-114591327-A | Indoline piperidine urea type TRPV1 antagonistic and MOR agonistic double-target-point medicine, preparation method and application | 河南大学 | 2022-06-07 | — | — | CN | disclosed |