Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 3/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
| ▸ | XDH | P47989 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29644503 | 0.76 | LIMK1 (0.35) | KDRABL1CHEK1MAP4K4CSF1R | |
| SCHEMBL30952541 | 0.72 | PI4KA (0.35) | PI4KAPI4K2BPI4K2API4KBKDR | |
| SCHEMBL22509642 | 0.68 | PI4KA (0.44) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL20417744 | 0.67 | PI4KA (0.43) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL1092848 | 0.67 | PI4KA (0.43) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL10051003 | 0.67 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL20567950 | 0.67 | MKNK2 (0.44) | EGFRKDM4EHSD17B10ALDH1A1MKNK2 | |
| SCHEMBL21127668 | 0.66 | PI4KA (0.42) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL30837303 | 0.66 | MAPKAPK2 (0.37) | KDRCHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL19812349 | 0.64 | DYRK1A (0.33) | KDRCHEK1MAP4K4CSF1RPRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240254117-A1 | PYRIMIDO-HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI RINGENE BIOPHARMA CO., LTD. (CN) | 2024-08-01 | — | — | US | disclosed |
| CN-114685487-B | Pyrimidine heterocyclic compounds, preparation method and application | 上海凌达生物医药有限公司 | 2024-04-19 | — | — | CN | disclosed |
| CN-114685487-A | Pyrimidine heterocyclic compound, preparation method and application | 上海凌达生物医药有限公司 | 2022-07-01 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240254117-A1 | PYRIMIDO-HETEROCYCLIC COMPOUNDS, AND PREPARATION METHOD THEREFOR AND USE THEREOF | TYMS, TYMP, SLC5A11 | PI4KA 1531/4885PI4K2B 1733/4885PI4K2A 1967/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.